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Observed performance metrics in laboratory models
Observed performance metrics in laboratory models
Research summary on SR-9011
SR-9011 is a synthetic small molecule that activates the nuclear receptors REV-ERBα and REV-ERBβ
SR-9011 is technically not a SARM — it is a Rev-ErbA agonist with similar effects to SR-9009.
In research settings, it has been shown to:
✔ Increase metabolic activity.
✔ Improve endurance.
✔ Support weight management.
⚡ METABOLIC BOOST:
Enhances mitochondrial activity and metabolic rate.
🏅 ATHLETIC PERFORMANCE:
Enhances muscle function and endurance in preclinical research.
📏️ BODY WEIGHT CONTROL:
Promotes fat utilization over carbohydrate reliance.
1. Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence
2. The Effect of Rev-erbα Agonist SR9011 on the Immune Response and Cell Metabolism of Microglia
https://doi.org/10.3389/fimmu.2020.550145
3. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists
4. In-vitro metabolic studies of REV-ERB agonists SR9009 and SR9011
5. Anti-proliferative actions of a synthetic REV-ERBα/β agonist in breast cancer cells
https://www.sciencedirect.com/science/article/pii/S0006295215003263
Research summary on ACP-105
Motor Coordination & Neuroprotection
ACP-105 is a Selective Androgen Receptor Modulator (SARM) — researched for its anabolic effects inmuscle and bone.
In research settings, it has been shown to:
✔ Promote muscle growth in wasting conditions.
✔ Support bone density maintenance
✔ Enhance physical performance.
🦾 MUSCLE PRESERVATION:
ACP-105 has shown potential to prevent muscle loss during periods of disuse
🛠️ BONE SUPPORT:
Improves bone mineral density in preclinical models.
🏅 ATHLETIC PERFORMANCE:
May increase exercise capacity and recovery rates
1. Synthesis, structure–activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators
https://pubmed.ncbi.nlm.nih.gov/19856921/
2. Effects of the SARM ACP-105 on rotorod performance and cued fear conditioning in (irradiated) female mice
https://pubmed.ncbi.nlm.nih.gov/21219889/
3. Nonsteroidal SARMs and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer’s diseas
https://pubmed.ncbi.nlm.nih.gov/24881457/
4. Identification of equine in vitro metabolites of SARMs for doping control
Research summary on GW-0742
Microglial Function & Glucose Regulation
GW-0742 is technically not a SARM — it is a PPARδ agonist, closely related to Cardarine(GW-501516).
In research settings, it has been shown to:
✔ Increase fatty acid metabolism.
✔ Improve cardiovascular endurance.
✔ Support healthy lipid profiles.
🥩 FAT UTILIZATION:
Shifts metabolism toward fatty acid oxidation during exercise.
⚡ ENDURANCE PERFORMANCE:
Increases exercise time to exhaustion in research models.
❤️🔥 CARDIOMETABOLIC HEALTH:
Improves markers of cardiovascular and metabolic health.
1. GW0742, a selective PPAR-β/δ agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury
https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bcp.13316
2. GW0742 rescued overweight and glucose tolerance, reduced hepatic inflammation, and favored β‑oxidation
https://www.sciencedirect.com/science/article/pii/S0303720718301059
3. GW0742 context‑dependent regulation in endothelial cells—suppressed metabolism in monolayers but enhanced during tubulogenesis
https://www.nature.com/articles/s41598-020-63900-0.pdf
4. PPARδ activation by GW0742 increases cardiac metabolic gene expression and lipid catabolism
https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0033-1348317
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