Explore the science behind SARMs—laboratory-tested data that demonstrate measurable outcomes in controlled research environments.
Button TextResearch Conducted by: Investigative labs under contract with NCI
Model Type: In vivo rodent assays and in vitro AR-binding simulations
Duration: Multi-phase observation over 21-day and extended timepoints
Outcomes:
Research Conducted by: Independent biochemical testing facilities
Model Type: Rodent-based endurance performance simulations and in vitro oxidative stress assays
Duration: 14-day exposure cycles
Outcomes: Significantly increased oxidative phosphorylation markers, lipid turnover enzymes, and mitochondrial biogenesis indicators
Conducted by: Regulated endocrine assay platforms
Model Type: Non-human GH/IGF-1 axis response frameworks
Duration: Variable exposure timelines including 12-month assay duration
Outcomes: Marked increases in anabolic signaling peptides and structural tissue markers without observed toxicity in monitored tissues
Research Conducted by: GTx Inc. – preclinical test systems
Model Type: Tissue-selective binding simulations and mass-analogue test environments
Duration: Up to 21-day cycles across dose-tiered exposures
Outcomes: Demonstrated anabolic response in skeletal-targeted tissues, with maintained selectivity over off-target androgenic zones
Conducted by: Metabolic and circadian rhythm research programs
Model Type: Murine models and synchronized in vitro cell cycles
Duration: 7–21 days depending on assay phase
Outcomes: Increased mitochondrial biogenesis, fatty acid oxidation rates, and improved circadian gene expression alignment