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Observed performance metrics in laboratory models
Observed performance metrics in laboratory models
Research summary on GSK2881078
Designed to treat muscle weakness and cachexia, particularly in aging and chronic illness contexts.
GSK-2881078 is a Selective Androgen Receptor Modulator (SARM) — investigated for age-relatedmuscle loss and physical function decline.
In research settings, it has been shown to:
✔ Increase lean muscle mass in older adults
✔ Enhance walking speed and physical capacity.
✔ Improve muscle strength.
⚙️ SARCOPENIA MANAGEMENT:
Has been shown to counteract muscle loss in age-related sarcopenia models.
➡️ FUNCTIONAL MOBILITY:
Improves mobility metrics such as walking speed and stair-climbing power.
⚡️ STRENGTH IMPROVEMENT:
Increases in grip and leg strength have been observed in trials.
1. Safety, tolerability, pharmacokinetics, and pharmacological effects of GSK 2881078 in healthy subjects
https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.13316
2. GSK 2881078 produces dose-dependent increases in lean mass in older adults
https://academic.oup.com/jcem/article/103/9/3215/5047294
3. SARM treatment for muscle weakness in COPD: Phase II trial
https://thorax.bmj.com/content/78/3/258
4. Clinical trial registration: 13-week SARM GSK 2881078 in older men and post-menopausal women with COPD
https://clinicaltrials.gov/study/NCT03359473
5. Structural comparison of RAD-140, GLPG 0492, and GSK 2881078 via docking studies
https://www.sciencedirect.com/science/article/pii/S0960076018306885
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