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Observed performance metrics in laboratory models
Observed performance metrics in laboratory models
Research summary on SR-9009 (also known as Stenabolic).
SR-9009 (Stenabolic) is technically not a SARM
SR-9009 (Stenabolic) is technically not a SARM — it is a Rev-ErbA agonist, influencing circadian rhythm and metabolism.
In research settings, it has been shown to:
✔ Increase metabolic rate.
✔ Enhance endurance performance.
✔ Support fat loss.
⚡ METABOLIC ACTIVATION:
Boosts basal metabolic rate and energy expenditure in preclinical studies.
🔥 ENDURANCE GAINS:
Improves running capacity in animal models.
🥩 FAT LOSS SUPPORT:
Enhances fat oxidation during exercise and rest.
1. Amador, Ariadna, Huitron-Resendiz, Salvador, Roberts, Amanda J, Kamenecka, Theodore M, Solt, Laura A, & Burris, Thomas P (2016). Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation.. PloS one.
https://doi.org/10.1371/journal.pone.0162452
2. Amador, Ariadna, Kamenecka, Theodore M, Solt, Laura A, & Burris, Thomas P (2018). REV-ERBβ is required to maintain normal wakefulness and the wake-inducing effect of dual REV-ERB agonist SR9009.. Biochemical pharmacology.
https://doi.org/10.1016/j.bcp.2018.01.009
3. Amador, Ariadna, Wang, Yongjun, Banerjee, Subhashis, Kameneka, Theodore M, Solt, Laura A, & Burris, Thomas P (2016). Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression.. PloS one.
https://doi.org/10.1371/journal.pone.0151014
4. Amir, Mohammed, Campbell, Sean, Kamenecka, Theodore M, & Solt, Laura A (2020). Pharmacological modulation and genetic deletion of REV-ERBα and REV-ERBβ regulates dendritic cell development.. Biochemical and biophysical research communications.
https://doi.org/10.1016/j.bbrc.2020.05.012
5. Borrmann, Helene, Davies, Rhianna, Dickinson, Matthew, Pedroza-Pacheco, Isabela, Schilling, Mirjam, Vaughan-Jackson, Alun, ... Zhuang, Xiaodong (2020). Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication.. Scientific reports.
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