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Observed performance metrics in laboratory models
Observed performance metrics in laboratory models
Research summary on MK-677
MK-677 (Ibutamoren) is technically not a SARM
MK-677 (Ibutamoren) is technically not a SARM — it is a growth hormone secretagogue, stimulating GH and IGF-1 release.
In research settings, it has been shown to:
✔ Increase growth hormone and IGF-1 levels.
✔ Promote muscle gain and fat loss.
✔ Improve sleep quality and recovery.
⚡ HORMONE BOOST:
MK-677 increases circulating growth hormone and IGF-1, supporting anabolic processes.
📊 BODY COMPOSITION:
May promote lean mass gains while reducing body fat percentage.
🔄 SLEEP & RECOVERY:
Improves REM sleep and overall recovery quality.
1. Abdul Ghafoor, Naeem, Rasuli, Sabina, Tanriverdi, Özgür, & Yildiz, Ayşegül (2025). Investigating the P53-dependent anti-cancer effect of ibutamoren in human cancer cell lines.. Basic & clinical pharmacology & toxicology.
https://doi.org/10.1111/bcpt.14111
2.Adunsky, Abraham, Chandler, Julie, Heyden, Norman, Lutkiewicz, Jeannine, Scott, Boyd B, Berd, Yuliya, ... Papanicolaou, Dimitris A (2011). MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study.. Archives of gerontology and geriatrics.
https://doi.org/10.1016/j.archger.2010.10.004
3. Arnott, Gareth, Brice, Heloise, Clayden, Jonathan, & Blaney, Emma (2008). Electrophile-induced dearomatizing spirocyclization of N-arylisonicotinamides: a route to spirocyclic piperidines.. Organic letters.
https://doi.org/10.1021/ol801092s
4. Bayes, M, Rabasseda, X, & Prous, J R (2006). Gateways to clinical trials.. Methods and findings in experimental and clinical pharmacology. PMID: 17200730
5. Bedendi, I, Gallo, M P, Malan, D, Levi, R C, & Alloatti, G (2001). Role of endothelial cells in modulation of contractility induced by hexarelin in rat ventricle.. Life sciences.
https://doi.org/10.1016/s0024-3205(01)01312-1
6. Bennett, Kirstie A, Langmead, Christopher J, Wise, Alan, & Milligan, Graeme (2009). Growth hormone secretagogues and growth hormone releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor.. Molecular pharmacology.
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