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Observed performance metrics in laboratory models
Observed performance metrics in laboratory models
Research summary on YK-11 (also known as Myostatin Inhibitor YK-11).
YK-11 is a Selective Androgen Receptor Modulator (SARM)
YK-11 is a Selective Androgen Receptor Modulator (SARM) — unique for also acting as a myostatin inhibitor, potentially unlocking greater muscle growth.
In research settings, it has been shown to:
✔ Increase muscle cell differentiation and size.
✔ Reduce myostatin activity in muscle tissue.
✔ Support rapid strength development.
🚫 MYOSTATIN INHIBITION:
YK-11’s ability to down regulate myostatin expression may allow for greater muscle hypertrophy than SARMs without this effect.
⚡ ACCELERATED STRENGTH:
Research models indicate faster increases in muscular strength compared to baseline.
📈 CELLULAR GROWTH:
By promoting follistatin expression, YK-11 supports muscle cell development and repair.
1. Harding, Caitlin, Viljanto, Marjaana, Habershon-Butcher, Jocelyn, Taylor, Polly, & Scarth, James (2023). Equine metabolism of the selective androgen receptor modulator YK-11 in urine and plasma following oral administration.. Drug testing and analysis.
https://doi.org/10.1002/dta.3425
2. Jeong, Ji-Ho, Kim, Minseon, & Kim, Yongae (2021). NMR structural studies and mechanism of action of Lactophoricin analogs as antimicrobial peptides.. Biochimica et biophysica acta. Biomembranes.
Research summary on MK-677
MK-677 (Ibutamoren) is technically not a SARM
MK-677 (Ibutamoren) is technically not a SARM — it is a growth hormone secretagogue, stimulating GH and IGF-1 release.
In research settings, it has been shown to:
✔ Increase growth hormone and IGF-1 levels.
✔ Promote muscle gain and fat loss.
✔ Improve sleep quality and recovery.
⚡ HORMONE BOOST:
MK-677 increases circulating growth hormone and IGF-1, supporting anabolic processes.
📊 BODY COMPOSITION:
May promote lean mass gains while reducing body fat percentage.
🔄 SLEEP & RECOVERY:
Improves REM sleep and overall recovery quality.
1. Abdul Ghafoor, Naeem, Rasuli, Sabina, Tanriverdi, Özgür, & Yildiz, Ayşegül (2025). Investigating the P53-dependent anti-cancer effect of ibutamoren in human cancer cell lines.. Basic & clinical pharmacology & toxicology.
https://doi.org/10.1111/bcpt.14111
2. Arnott, Gareth, Brice, Heloise, Clayden, Jonathan, & Blaney, Emma (2008). Electrophile-induced dearomatizing spirocyclization of N-arylisonicotinamides: a route to spirocyclic piperidines.. Organic letters.
https://doi.org/10.1021/ol801092s
3. Bedendi, I, Gallo, M P, Malan, D, Levi, R C, & Alloatti, G (2001). Role of endothelial cells in modulation of contractility induced by hexarelin in rat ventricle.. Life sciences.
https://doi.org/10.1016/s0024-3205(01)01312-1
4. Bennett, Kirstie A, Langmead, Christopher J, Wise, Alan, & Milligan, Graeme (2009). Growth hormone secretagogues and growth hormone releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor.. Molecular pharmacology.
Research summary on Ostarine (also known as MK-2866).
Ostarine, also known as Enobosarm or MK-2866, is a non-steroidal selective androgen receptor modulator.
Ostarine (MK-2866) is a Selective Androgen Receptor Modulator (SARM) — which means it selectively binds to androgen receptors in muscle and bone tissue, promoting anabolic activity without the same level of androgenic effects seen with traditional anabolic steroids.
In research settings, it has been shown to:
✔ Increase lean muscle mass while in a caloric deficit.
✔ Improve muscle strength and functional performance
✔ Support bone density and joint health during periods of muscle atrophy risk.
📏 LEAN MUSCLE RETENTION:
In studies, Ostarine has demonstrated the ability to preserve and even increase lean muscle mass during periods of calorie restriction or immobilization, helping maintain strength and physical performance.
🛠️ BONE & JOINT SUPPORT:
Ostarine has shown positive effects on bone mineral density and may support joint health, potentially reducing injury risk during high-intensity training or rehabilitation.
⚡ FUNCTIONAL PERFORMANCE:
By enhancing anabolic signaling in muscle tissue, Ostarine can improve endurance, recovery rate, and overall functional output without significantly increasing water retention or fat mass.
1. Dalton JT et al., 2011 — Double-blind phase II in healthy elderly men & postmenopausal women
2. Dobs AS et al., 2013 — Phase II RCT in cancer patients with muscle wasting
3. Coss CC et al., 2016 — Clinical pharmacokinetic drug–drug interactionstudies
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