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Observed performance metrics in laboratory models
Observed performance metrics in laboratory models
Research summary on GW-0742
Microglial Function & Glucose Regulation
GW-0742 is technically not a SARM — it is a PPARδ agonist, closely related to Cardarine(GW-501516).
In research settings, it has been shown to:
✔ Increase fatty acid metabolism.
✔ Improve cardiovascular endurance.
✔ Support healthy lipid profiles.
🥩 FAT UTILIZATION:
Shifts metabolism toward fatty acid oxidation during exercise.
⚡ ENDURANCE PERFORMANCE:
Increases exercise time to exhaustion in research models.
❤️🔥 CARDIOMETABOLIC HEALTH:
Improves markers of cardiovascular and metabolic health.
1. GW0742, a selective PPAR-β/δ agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury
https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bcp.13316
2. GW0742 rescued overweight and glucose tolerance, reduced hepatic inflammation, and favored β‑oxidation
https://www.sciencedirect.com/science/article/pii/S0303720718301059
3. GW0742 context‑dependent regulation in endothelial cells—suppressed metabolism in monolayers but enhanced during tubulogenesis
https://www.nature.com/articles/s41598-020-63900-0.pdf
4. PPARδ activation by GW0742 increases cardiac metabolic gene expression and lipid catabolism
https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0033-1348317
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